Nematodes as Model Organisms

June 2022
More details
  • Publisher
  • Published
    9th June 2022
  • ISBN 9781789248791
  • Language English
  • Pages 376 pp.
  • Size 6" x 9"

Nematodes are small multicellular organisms that have been used as biological models since the 1960s. For example, Caenorhabditis elegans is a free-living nematode worm, about 1mm in length, that lives in temperate soil environments. It is made up of about 1000 cells, and has a short life cycle of only two weeks. It was the first multicellular organism to have its whole genome sequenced.

The book summarizes the importance of nematodes as model organisms in the fields of genetics, developmental biology, neurobiology, pharmacology, nutrition, ecology and parasitology.

Of interest to a broad audience across a wide spectrum of disciplines, this book is useful for biologists working on comparative studies to investigate biological processes across organisms; medical scientists and pharmacologists for exploration of drugs and medicine (including the use of genome editing to eliminate diseases); ecologists considering nematodes as indicators for environment changes; and parasitologists for host-parasite interactions. Many other researchers can use this book as a benchmark for the broad implications of nematology research on other aspects of science.

“In summary, this very readable book will be of interest not only to nematologists and C. elegans specialists who want to broaden their perspectives on how nematodes have impacted various fields, but also to other biologists, medical scientists, pharmacologists, educators, naturalists, and citizen scientists who want to feed their curiosity about many of life’s mysteries and how they are being addressed through the vast and growing toolkit provided by nematodes.”

The Quarterly Review of Biology

Section 1: Biological Systems

1: The genus Pristionchus: a model for phenotypic plasticity, predatory behavior, self-recognition and other complex traits

2: Aging

3: Entomopathogenic nematodes as a model for probing the insect immune system

4: The use of the Root Knot Nematodes, Meloidogyne spp., for studying biotrophic parasitic interactions

5: Nematodes as a model for symbiosis

6: Nematode pharmacology; neurotransmitters, receptors and experimental approaches

Section 2: Ecology and Toxicology

7: Nematodes as Ecological and Environmental Indicators

8: Soil Ecology

9: Stress and Survival Mechanisms

10: Molecular Toxicology in Caenorhabditis elegans

11: Nematode use for testing theoretical models of behavioral ecology

Section 3: Biological control of pests

12: Entomopathogenic Nematodes As Models For Inundative Biological Control

13: Parasitic Nematodes and their Symbiosis with Bacteria: Model Systems for Studying Parasitism and Pathogenesis

Chapter 14: Genetic Improvement of Beneficial Organisms

Itamar Glazer

Itamar Glazer is a Researcher at the Agricultural Research Organization (ARO), Volcani Center, Israel.

David I. Shapiro-llan

Dr. David I. Shapiro-Ilan is a Supervisory Research Entomologist at USDA-ARS, Georgia. His research focuses on invertebrate pathology/microbial control. Areas of interest emphasize the study of entomopathogenic nematodes and include biological control applications, production and formulation technology, and studies on nematode behavior (especially foraging dynamics). Dr. Shapiro-Ilan has published 180 peer-reviewed journal articles plus 24 book chapters and more than 40 trade journal/extension articles; he has co-edited 3 books and is inventor on 7 patents. Selected awards include Fellow of the Society of Nematologists, EEO/Civil Rights, Excellence in IPM (SEB-ESA, 2012), and over $7 million as PI/co-PI on competitive grants. He is currently the Editor-in-Chief for the Journal of Nematology, and Editor for the Journal of Invertebrate Pathology.

Paul W. Sternberg

Paul Sternberg is Professor of Biology at Caltech.

nematodes as biological models; Caenorhabditis elegans; C. elegans; model organism; nematode aging; nematode environmental indicator; nematode genetics research