December 1999
More details
  • Publisher
    World Health Organization
  • Published
    1st December 1999
  • ISBN 9789283230045
  • Language English
  • Pages 329 pp.
  • Size 6.5" x 9.5"
  • Images Tables, Graphs and Exhibits

Retinoids are a class of compounds structurally related to vitamin A. More than 2500 retinoids have been synthesized and tested for biological activity. Nine of these were evaluated as agents for cancer chemoprevention by an international group of experts at a meeting held in March 1999. Some are agents in clinical use for psoriasis or severe acne and others are undergoing clinical trials for prevention of second primary tumours in patients with head and neck tumours or breast cancer while all-transretinoic acid is used in the treatment of acute promyelocytic leukaemias. The toxicity of these agents was subjected to close scrutiny by the working group which concluded that for nearly all these agents even if they are eventually shown to be effective for cancer prevention in humans their toxicity is likely to limit their use.

List of Participants
General Remarks
1) All-trans-Retinoic Acid
2) 13-cis-Retinoic Acid
3) 9-cis--Retinoic Acid
4) 4-Hydroxyphenyl-Retinamide
5) Etretinate
6) Acitretin
7) N-Ethylretinamide
8) Targretin
9) LGD 1550

The International Agency for Research on Cancer

The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.