IARC Monographs on the Evaluation of the Carcinogenic Risks to Humans Series 108

Some Drugs and Herbal Medicines

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Paperback
July 2016
9789283201465
More details
  • Publisher
    World Health Organization
  • Published
    18th July 2016
  • ISBN 9789283201465
  • Language English
  • Pages 434 pp.
  • Size 8.25" x 10.5"
$66.00

This volume of the IARC Monographs provides an assessment of the carcinogenicity of 14 drugs and herbal products.

The IARC Monographs Working Group relied mainly on epidemiological studies to evaluate the carcinogenic hazard to humans exposed to the drugs digoxin (widely prescribed for the treatment of chronic heart failure), pioglitazone (used for the treatment of type 2 diabetes mellitus), and hydrochlorothiazide (used to treat hypertension).

Other agents evaluated included the drugs primidone, sulfasalazine, pentosan polysulfate sodium, and triamterene, and five herbal products (or their components): Aloe vera whole leaf extract, goldenseal root powder, Ginkgo biloba leaf extract, kava extract, and pulegone. In view of the limited agent-specific information available from epidemiological studies, assessments of these agents relied mainly on carcinogenicity bioassays to reach conclusions as to the carcinogenic hazard to exposed humans.

International Agency for Research on Cancer

The International Agency for Research on Cancer (IARC) is part of the World Health Organization. IARC's mission is to coordinate and conduct research on the causes of human cancer, the mechanisms of carcinogenesis, and to develop scientific strategies for cancer control. The Agency is involved in both epidemiological and laboratory research and disseminates scientific information through publications, meetings, courses, and fellowships.