River Publishers Series in Biotechnology and Medical Technology Forum Series

Stem Cell Biology and Regenerative Medicine Edition 2

September 2021
More details
  • Publisher
    River Publishers
  • Published
    16th September 2021
  • ISBN 9788770224031
  • Language English
  • Pages 400 pp.
  • Size 6" x 9"
  • Request Exam Copy
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September 2021
More details
  • Publisher
    River Publishers
  • Published
    22nd September 2021
  • ISBN 9788770224024
  • Language English
  • Pages 400 pp.
  • Size 6" x 9"

The study of stem cell biology is under intensive investigation. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell and gene therapy.

The aim of this book is to provide readers and researchers with timely and accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on conferences given by recognized scientists involved in the international master course on stem cell biology at Sorbonne Université in Paris.

Preface. Pierre Charbord and Charles Durand

1) General concepts 

Stem cell concepts. Charles Durand and Pierre Charbord.

Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld.

Repair of DNA double-strand breaks in adult stem cells. Leyla Vahidi Ferdousi, Haser Hasan Sutcu and Miria Ricchetti.

Haematopoietic stem cell niches in the bone marrow. Claire Fielding and Simon Mendez-Ferrer.

Computational models of spatio-temporal stem cell organization. Torsten Thalheim and Joerg Galle.

Omics investigations. Christophe Desterke.

2) Pluripotent stem cells and regeneration

The regulatory network of X chromosome inactivation. Jeffrey Boeren, Sabina Jasarevic and Joost Gribnau.

Pluripotent stem cells : a common evolutionary origin? Guillaume Balavoine.

Directed differentiation of human-induced pluripotent stem cells into hepatic cells: a transposable example of disease modeling and regenerative medicine applications. Antonietta Messina, Eleanor Luce and Anne Dubart-Kupperschmitt.

Hydra and stem cell evolution. Alexander Klimovich and Thomas Bosch.

Regeneration in amniotic vertebrates. Prayag Murawala and Dunja Knapp.

Stem cells and regeneration in plants. Marco Da Costa and Philippe Rech.

3) Adult stem cells

Hematopoietic development in vertebrates. Hanane Khoury, Thierry Jaffredo and Laurent Yvernogeau

Developmental biology of hematopoietic stem cells: Non-cell autonomous mechanisms. Leslie Nitsche and Katrin Ottersbach.

Biology of hematopoietic stem cells in the adult. Rima Haddad, Francoise Pflumio and Marie-Laure Arcangeli.

Epithelial stem cells in the skin. Romain Fontaine, Benedicte Oules, Mathieu Castela and Selim Aractingi.

Mammary stem cells. Silvia Fre.

Intestinal stem cells. Aline Stedman.

Neural stem cells: adult and regenerative aspects. Nathalie Kubis and Martin Catala.

Bone marrow mesenchymal stem cells: from stemness to stromal property of hematopoietic support. Pierre Charbord.

Dental stem cells. Anne-Margaux Collignon, Caroline Gorin, Catherine Chaussain and Anne Poliard.

Stem cells and retina: from regeneration to cell therapy. Olivier Goureau, Giuliana Gagliardi and Gael Orieux.

4) Stem cell-related diseases and therapy using stem cells

Leukemic stem cells.Pierre Hirsch and François Delhommeau.

Glioblastoma stem cells. Nathalie Magne, Sandra E Joppe, Franck Bielle and Emmanuelle Huillard.

Cardiac tissue engineering for repair and regeneration of the heart. Pierre Joanne and Onnik Agbulut.

Stem cells for red blood cell production. Laurence Guyonneau-Harmand and Helene Lapillone.

Hematopoietic stem cells, gene and cell therapy. Emmanuelle Six and Isabelle Andre-Schmutz.

Prospectives for therapy with stem cells in skeletal muscular diseases. Elisa Negroni, Gillian Butler-Browne and Vincent Mouly.

5) Reglementary and philosophical aspects

Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Samuel Arrabal.

Stem cell conceptual clarifications. Lucie Laplane.

Future outlook. Olivera Miladinovic, Pierre Charbord and Charles Durand.

Charles Durand

Charles Durand received his PhD in Developmental Biology from the University Pierre and Marie Curie (UPMC, Paris). He did his PhD in the laboratory of Prof. Jacques Charlemagne, where he studied the development of the immune system in the amphibian embryo. He did his postdoctoral training in the laboratory of Prof. Elaine Dzierzak (Erasmus Medical Center, The Netherlands) where he analyzed the molecular identity and cellular complexity of the AGM (Aorta-Gonads-Mesonephros) hematopoietic microenvironment in the mouse embryo. Since 2005, he became Associate Professor at UPMC in the laboratory of Dr. Thierry Jaffredo. His main research interests are the identification of the molecular mechanisms involved in the cross-talk between hematopoietic stem cells and stromal cells. He is the chairperson of the MSc Stem Cell Biology at UPMC.

Pierre Charbord

Pierre Charbord is an emeritus Inserm scientist. After his training as MD, he joined the French National Health Institute (Inserm) in 1979 and since that date has conducted research on both hematopoietic and mesenchymal stem cells, investigating their differentiation potentials, the niche formation and their potential implication in human diseases such as cancer. He was visiting scientist in Seattle from 1983 to 1986, where he collaborated with Jack W. Singer, studying the generation of stem cells in long-term bone marrow cultures. In 2000 and 2001, he was visiting scientist in Princeton, where he collaborated with Kateri Moore and Ihor Lemischka, studying the transcriptome of fetal liver stromal cells. He has contributed to more than 120 original publications and to several book chapters.

pluripotent stem cells; adult stem cells; ontogeny; phylogeny; differentiation; reprogramming; microenvironment; transcription; epigenetics; regeneration; repair; cancer; cell therapy; gene therapy; omics and computational biology; epistemology; regulatory issues