Lyme Disease Edition 2
An Evidence-based Approach
This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects.
Presented in full color throughout, this edition:
- Includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others).
- Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis.
- Discusses the controversies about "chronic Lyme disease," post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection.
As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.
PART I: BIOLOGICAL SUBSTRATE
1. Ticks: the Vectors of Lyme Disease
2. Borrelia: Biology of the Organism
3. Borrelia: Interactions with the Host Immune System
4. Laboratory Diagnostic Testing for Borrelia burgdorferi Infection
5. Persistence of Borrelia burgdorferi Infection after Antibiotic Treatment: What Can We Learn from Animal Models?
6. Global Epidemiology of Borrelia burgdorferi Infections
PART II: CLINICAL ASPECTS
7. Antibiotic Therapy for Infection Caused by Borrelia burgdorferi Sensu Lato
8. Lyme Borreliosis in the UK and Ireland
9. Lyme Borreliosis: the European Perspective
10. Erythema Migrans
11. Cardiac Involvement
12. Rheumatological Involvement
13. Nervous System Involvement
14. Lyme Disease in Children
15. The Psychology of ‘Post-Lyme Disease Syndrome’ and ‘Not Lyme’
16. Chronic Lyme Disease
17. Lyme Disease: the Great Controversy